The following are clinically substantial drug interactions with oxycodone. It's not an all-inclusive record — other medicine not stated in this article may bring about an conversation. Sizeable drug interactions contain:
Oxycodone produces respiratory melancholy via direct action at respiratory centers in the brain stem and depresses the cough reflex by direct effect on the center of your medulla.
Animal research To judge the carcinogenic prospective of oxycodone and acetaminophen have not been done.
Will not acquire a lot more than 4000 milligrams of acetaminophen on a daily basis. Phone your health practitioner for those who took a lot more than the advised dose.
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When co-administered with An additional CNS depressant, PERCOCET tablets may cause perilous additive central anxious technique or respiratory melancholy, which may lead to significant harm or Dying.
Opioid addiction refers to remaining struggling to quit making use of an opioid drug Irrespective of its harmful consequences and influence on your everyday life. Tolerance, physical dependence, and withdrawal are commonly connected to habit.
Zidovudine: The pharmacologic outcomes of zidovudine may very well be lessened thanks to enhanced non-hepatic or renal clearance of zidovudine.
In small doses, more info acetaminophen might cause elevated liver enzymes. Getting too much acetaminophen can result in liver destruction or liver failure. The potential risk of liver injury is increased if you already have liver issues, acquire warfarin, or drink much more than three alcoholic beverages each day.
Vigorous supportive therapy is required in intense website intoxication. Treatments to limit the continuing absorption in the drug have to be commonly done since the hepatic damage is dose dependent and occurs early in the middle of intoxication.
Animal reproductive reports haven't been performed with PERCOCET. It is also not regarded regardless of whether PERCOCET can result in fetal hurt when administered into a Expecting read more woman or can have an impact on reproductive ability.
Security hasn't been set up in little ones; warning or percocet avoidance is advised in Expecting and breastfeeding Women of all ages as infants could be born with opioid tolerance and frustrated respirations. On top of that, small concentrations of Percocet are found in breast milk.
Oxycodone was clastogenic during the human lymphocyte chromosomal assay within the presence of metabolic activation and during the mouse lymphoma assay with or with no metabolic activation.
PERCOCET tablets may perhaps obscure the prognosis or clinical class in people with acute abdominal ailments. Oxycodone may possibly aggravate convulsions in individuals with percocet convulsive disorders, and all opioids may induce or aggravate seizures in certain medical configurations.